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In brief, mouse electrocardiography was measured in females [Young ( n = 6), Old Con ( n = 8), and Old mAb ( n = 7)] and males [Young ( n = 5), Old Con ( n = 6), and Old mAb ( n = 5)], using a Visual Sonic Vevo2100 imaging system (FUJIFILM VisualSonics Inc, Toronto, ON)

The elevated Gln levels and Gln/Glu ratio observed in our adult ASD group may reflect an altered Gln-Glu cycle, potentially driven by modifications in astrocyte function or Gln transport, as suggested by previous postmortem studies [15]

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Arsenic is reported to activate PKC which activates MAPK pathway leading to the activation of various transcription factors like AP-1